A novel role for RGMa in modulation of bone marrow-derived dendritic cells maturation induced by lipopolysaccharide
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- 作者：Xuxu Xua ; Yan Gaoa ; Fengping Shanb ; Juan Fenga ; cmufengjuan@sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：APCs ; antigen presenting cells ; CNS ; central nervous system ; DCs ; dendritic cells ; EAE ; experimental autoimmune encephalomyelitis ; ELISA ; enzyme-linked immunosorbent assay ; GM-CSF ; granulocyte macrophage&ndash ; colony-stimulating factor ; IRAK-4 ; interleukin-1 receptor-associated kinase 4 ; IRF- 3 ; interferon regulatory factor 3 ; LPS ; lipopolysaccharide ; MACS ; magnetic activated cell sorting ; MOG ; myelin oligodendrocyte glycoprotein ; MS ; multiple sclerosis ; NTi ; negative control ; PBS ; phosphate bal
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：33
- 期：Complete
- 页码：99-107
- 全文大小：1491 K
文摘
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The expression of key surface molecules were decreased in RGMa-silenced DCs with LPS treatment.
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RGMa-transfected DCs reduced levels of IL-12p70 and TNF-α, and increased level of IL-10, after LPS treatment.
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RGMa-transfected DCs had a reduced ability to induce T cell activation and differentiation, after LPS treatment.