Activation of LILRB2 signal pathway in temporal lobe epilepsy patients and in a pilocarpine induced epilepsy model
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- 作者：Jiong Yuea ; 1 ; Wei Lia ; 1 ; Chao Lianga ; Bing Chena ; Xin Chena ; Lukang Wanga ; Zhenle Zanga ; Sixun Yub ; Shiyong Liua ; Song Lia ; dlisong3@163.com" class="auth_mail" title="E-mail the corresponding author ; Hui Yanga ; huiyangxinqiao@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AEDs ; antiepileptic drugs ; LIR ; leukocyte immunoglobulin-like receptor ; ITIMs ; immunoreceptor tyrosine-based inhibitory motifs ; MAG ; myelin-associated glycoprotein ; OMgp ; oligodendrocyte myelin glycoprotein ; mEPSC ; miniature excitatory postsynaptic current ; LTP ; long-term potentiation ; LTD ; long-term depression ; MCAO ; middle cerebral artery occlusion ; TSC ; tuberous sclerosis complex ; FCD ; focal cortical dysplasia ; CT ; computerized tomography ; MRI ; magnetic resonance imaging ; BCA ; bicinchoninic a
- 刊名：Experimental Neurology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：285
- 期：part_PA
- 页码：51-60
- 全文大小：3431 K
文摘
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The expression of LILRB2/PirB in patients with intractable TLE and model mice was dramatically increased, respectively.
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The downstream molecules of LILRB2/PirB have been activated in the epileptic foci of TLE patients.
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LILRB2/PirB and its downstream factors are highly expressed in neurons and astrocytes.
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The protein levels of LILRB2 negatively correlated with the frequency of seizures in TLE patients.