A recombinant fusion protein consisting of West Nile virus envelope domain III fused in-frame with equine CD40 ligand induces antiviral immune responses in horses

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• 作者：Shiliang A. Liu^a ; Muzammel Haque^a ; Brent Stanfield^a ; Frank M. Andrews^b ; Alma A. Roy^a ; Konstantin G. Kousoulas^a ; ^{vtgusk@lsu.edu}
• 关键词：West Nile virus ; Subunit vaccine ; Domain III ; CD40L ; Immune response
• 刊名：Veterinary Microbiology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：198
• 期：Complete
• 页码：51-58
• 全文大小：1128 K
• 卷排序：198

文摘

A subunit vaccine consisting of the E glycoprotein domain III fused in-frame to CD40L generates robust immune responses against West Nile virus (WNV). The CD40L-WNV-DIII protein generated high anti-DII specific antibody and strong neutralization titers against WNV. The CD40L-WNV-DII subunit vaccine stimulated CD4 + T amd CD8 + T cellular proliferation. CD40L could be utilized as a non-toxic, alternative adjuvant to boost the immunogenicity of subunit vaccines in horses.