Losartan and captopril treatment rescue normal thrombus formation in microfibril associated glycoprotein-1 (MAGP1) deficient mice
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- 作者：Tallita Vassequi-Silvaa ; Danielle Sousa Pereiraa ; Ana Clá ; udia C. Nery Dieza ; Guilherme G. Bragaa ; Juliana A. Godoyf ; Camila B. Mendesb ; Leonardo dos Santosc ; José ; E. Kriegerd ; Edson Antunesb ; Fá ; bio T.M. Costae ; Cristina P. Vicentef ; Claudio C. Wernecka ; cwerneck@unicamp.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Microfibril-associated glycoprotein ; Arterial thrombosis ; Transforming growth factor-β ; Antihypertensive drugs ; Extracellular matrix ; Matrix metalloproteinases
- 刊名：Thrombosis Research
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：138
- 期：Complete
- 页码：7-15
- 全文大小：1259 K
文摘
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Deficiency of MAGP-1 alters the interaction between thrombus and the vessel wall prolonging the occlusion time.
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MAGP-1 deficiency increases gelatinases activity probably by increased TGF-β activity levels.
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Treatment with losartan and captopril decrease gelatinases activity and restores normal occlusion time.