Modulation of P-glycoprotein activity by novel synthetic curcumin derivatives in sensitive and multidrug-resistant T-cell acute lymphoblastic leukemia cell lines
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- 作者：Edna Ookoa ; Tahseen Alsalimb ; Bahjat Saeedb ; Mohamed E.M. Saeeda ; Onat Kadioglua ; Hanna S. Abboc ; Salam J.J. Titinchic ; stitinchi@uwc.ac.za" class="auth_mail" title="E-mail the corresponding author ; Thomas Effertha ; efferth@uni-mainz.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：ABC ; ATP-binding cassette ; MDR ; multidrug resistance ; NBD ; nucleotide-binding domain ; P-gp ; P-glycoprotein ; QSAR ; quantitative structure&ndash ; activity relationship ; TM ; transmembrane
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：15 August 2016
- 年：2016
- 卷：305
- 期：Complete
- 页码：216-233
- 全文大小：2059 K
文摘
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Novel derivatives of curcumin in reversing multidrug resistance (MDR)
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Biological and Insilco assays to assess effect on P-glycoprotein (P-gp)
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Curcumin synthetic derivatives as possible lead compound against multidrug resistant cancer