Concentrations of pregnancy-associated glycoproteins 1 (PAG-1) and 2 (PAG-2) in response to experimental infection on day 110 of gestation with N. caninum in dairy heifers.

Significant lower relative proportions of bi- and mono-nucleate trophoblast cells was detected in non-aborting Neospora-infected heifers 42 days post infection, compared to non-infected animals.

Non-aborting Neospora-infected dairy heifers showed a brief transient reduction in PAG-1 and PAG-2 concentrations from 7 to 14 days post infection.

Infected aborting dams showed a dramatic decline in PAGs until undetectable levels were recorded on day 42 post infection.

Following infection with N. caninum, heifers suffer placental damage, though, in some animals, this damage will be overcome and pregnancy will successfully continue to term.