Neutralization breadth and potency of serum derived from recently human immunodeficiency virus type 1-infected Thai individuals

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• 作者：Nithinart Chaitaveep^a ; Piraporn Utachee^b ; Thippawan Chuenchitra^a ; Nicos Karasavvan^a ; Naokazu Takeda^b ; ^c ; Masanori Kameoka^c ; ^d ; ^{mkameoka@port.kobe-u.ac.jp" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Recent HIV-1 infection ; Neutralization ; CRF01_AE ; Thailand
• 刊名：Microbes and Infection
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：18
• 期：5
• 页码：346-353
• 全文大小：243 K

文摘

Neutralizing antibody responses play important roles in controlling several viral infections including human immunodeficiency virus type 1 (HIV-1). Potent and broad neutralizing antibody responses have been reported in some HIV-1-infected individuals; therefore, elucidating the mechanisms underlying neutralizing antibody responses will provide important information for the development of anti-HIV-1 vaccines. We herein performed a comparative study on the neutralization breadth and potency of serum samples collected from Thai individuals recently and chronically infected with HIV-1. Neutralization tests using a series of envelope glycoproteins (Env)-recombinant viruses revealed that although several serum samples derived from recently infected individuals did not show any HIV-1-specific neutralizing activity, the remaining serum samples exhibited neutralizing activity not only for recombinant viruses with CRF01_AE Env, but also for viruses with subtypes B and C Env. Furthermore, some serum samples derived from recently infected individuals showed the neutralization potency. Our results may provide a deeper insight into the characteristics of neutralizing antibody responses that develop during the course of HIV-1 infection among individuals in Thailand.