SUMO-modification and elimination of the active DNA demethylation enzyme TDG in cultured human cells
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- 作者：Taishi Moriyamaa ; Yuka Fujimitsua ; Yushi Yoshikaia ; Takashi Sasanoa ; Koji Yamadaa ; Masataka Murakamia ; Takeshi Uranob ; Kaoru Sugasawac ; Hisato Saitoha ; d ; hisa@kumamoto-u.ac.jp" class="auth_mail
- 关键词：Small ubiquitin-related modifier (SUMO) ; Thymine DNA glycosylase (TDG) ; Ring finger protein 4 (RNF4) ; SUMO-targeted ubiquitin ligase (STUbL) ; Cell cycle ; DNA demethylation
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：9 May 2014
- 年：2014
- 卷：447
- 期：3
- 页码：419-424
- 全文大小：1171 K
文摘
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TDG and SUMOylated TDG fluctuate during cell cycle.
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TDG and SUMOylated TDG are eliminated in S phase cells.
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TDG interacts with RNF4 in a SUMOylation-independent manner.
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RNF4-depletion has a negligible impact on TDG elimination during S phase.