Inhibition of High Mobility Group Box 1-Toll-Like Receptor-4 Signaling by Glycyrrhizin Contributes to the Attenuation of Cold Ischemic Injury of Liver in a Rat Model
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文摘
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We evaluate the effect of glycyrrhizin on liver graft kept under cold storage.
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We compare the changes of graft preserved in solution with addition of glycyrrhizin.
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Glycyrrhizin attenuate ischemic injury of graft during reperfusion.
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Protective mechanism of glycyrrhizin is partially attributable to the inhibition of TLR4 signaling.