Ligustilide ameliorates neuroinflammation and brain injury in focal cerebral ischemia/reperfusion rats: involvement of inhibition of TLR4/peroxiredoxin 6 signaling
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- 作者：Xi Kuang1 ; Liang-Fen Wang1 ; Lu Yu1 ; 2 ; Yong-Jie Li1 ; Yan-Nan Wang ; Qian He ; Chu Chen ; Jun-Rong Du ; dujr07@gmail.com" class="auth_mail ; dujr_1@163.com" class="auth_mail
- 关键词：Ischemic stroke ; Neuroinflammation ; Immunomodulation ; TLR4 signaling ; Peroxiredoxin 6 ; NF-魏B ; STAT3 ; Ligustilide ; Free radicals
- 刊名：Free Radical Biology and Medicine
- 出版年：June 2014
- 年：2014
- 卷：71
- 期：Complete
- 页码：165-175
- 全文大小：5977 K
文摘
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Brain ischemia induced release of peroxiredoxin 6 into cerebrospinal fluid.
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Toll-like receptor 4 and peroxiredoxin 6 levels were increased in ischemic brain.
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Ligustilide attenuated postischemic neuroinflammation and brain injury.
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Ligustilide reduced Toll-like receptor 4/peroxiredoxin 6 in ischemic brain.
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Toll-like receptor 4 signaling was inhibited by ligustilide.