Acylated iridoid glycosides and acylated rhamnopyranoses from Gmelina arborea flowers

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• 作者：Wei Gu ; Xiao-Jiang Hao ; Hong-Xin Liu ; Yue-Hu Wang ; Chun-Lin Long
• 关键词：Gmelina arborea ; Iridoid glycosides ; Acylated rhamnopyranoses ; Phenylethanoid ; Cytoprotective activity
• 刊名：Phytochemistry Letters
• 出版年：2013
• 出版时间：November, 2013
• 年：2013
• 卷：6
• 期：4
• 页码：681-685
• 全文大小：416 K

文摘

Nine acylated iridoid glycosides (1-9), five acylated rhamnopyranoses (10-14) and verbascoside (15) were isolated from Gmelina arborea flowers, including 5 new compounds (1, 2, and 10-12). The cytoprotective activity of 11 selected compounds (1-8, 10, 11, and 15) against CCl₄-induced cytotoxicity on liver was determined. Compounds 1, 2, 4, 7, 8 and 15 displayed hepatoprotective activity. 6-O-¦Á-l-(2¡å, 3¡å-di-O-trans-p-hydroxycinnamoyl)rhamnopyranosylcatalpol (2) exhibited the most potent cytoprotective effect with an EC₅₀ value of 42.5 ¦ÌM (SI = 19.3) compared with biphenyldimethylesterate (DDB, EC₅₀ = 277.3 ¦ÌM, SI = 9.8) and bicylo-ethanol (EC₅₀ = 279.2 ¦ÌM, SI = 12.2). Among the acylated iridoid glycosides, the compounds (2 and 8) containing phenolic hydroxy groups were more active than were those lacking them.