C-di-GMP Synthesis: Structural Aspects of Evolution, Catalysis and Regulation
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- 作者：Tilman Schirmer ; tilman.schirmer@unibas.ch" class="auth_mail" title="E-mail the corresponding author
- 关键词：c-di-GMP ; cyclic di-guanosine monophosphate ; GTP ; guanosine triphosphate ; cAMP ; cyclic adenosine monophosphate ; cNMP ; cyclic nucleoside monophosphate ; GGDEF domain ; GGDEF motif-containing diguanylate cyclase domain ; EAL domain ; EAL motif-containing c-di-GMP phosphodiesterase ; PAS ; Per-Arnt-Sim ; GAF ; cGMP phosphodiesterase/adenylate cyclase/FhlA transcriptional activator ; PHY ; phytochrome specific ; FAD ; flavin adenine dinucleotide ; FMN ; flavin mononucleotide ; Ip ; primary inhibition site ; Is ; seco
- 刊名：Journal of Molecular Biology
- 出版年：2016
- 出版时间：25 September 2016
- 年：2016
- 卷：428
- 期：19
- 页码：3683-3701
- 全文大小：3541 K
文摘
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C-di-GMP is a multivalent molecule with well-defined backbone geometry.
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The catalytic GGDEF domain can be regulated by various accessory domains.
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Dimeric input and catalytic domains are typically linked by a parallel coiled coil.
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A signal-induced change in the coiled-coil geometry is predicted to affect activity.
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The coiled-coil linker allows modular combination of input and output function.