Characterization of Anti-HIV Lignans from Larrea tridentata

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• 作者：Gnabre ; John ; Huang ; Ru Chih C. ; Bates ; Robert B. ; Burns ; Jennifer J. ; Caldera ; Sriyani ; Malcomson ; Mark E. ; et. al.
• 刊名：Tetrahedron
• 出版年：1995
• 出版时间：November 6, 1995
• 年：1995
• 卷：51
• 期：45
• 页码：12203-12210
• 全文大小：302 K

文摘

Fractions from Larrea tridentata with anti-HIV-1 activity (specifically, inhibition of HIV Tat transactivation) were analyzed by GC/MS and NMR and found to contain lignans 1a-i and 2a-d. Assay-guided purification by countercurrent chromatography established 1g (mal. 4) to be especially active. Compounds1b-f,h,i and 2d are new.