- 作者：K Pradeepa ; V Krishna<sup> ; sup><sup>krishnabiotech2003@gmail.comsup> ; Venkatesh ; Kumar K Girish ; Santosh Kumar SR ; Joy H Hoskeri ; AU Gnanesh
- 关键词：Delonix elata ; Acute toxicity ; Abdominal writhing method ; Tail flick method
- 刊名：Asian Pacific Journal of Tropical Biomedicine
- 出版年：2012
- 出版时间：January, 2012
- 年：2012
- 卷：2
- 期：1_supp_S
- 页码：S229-S231
- 全文大小：1K
ss=""h4"">Objective
To evaluate antinociceptive property of the leaf extract of Delonix elata (Linn.).ss=""h4"">Methods
Antinociceptive activity was evaluated by abdominal writhing and tail flick methods in Swiss albino mice. Acetyl salicylic acid was used as standard drug.
ss=""h4"">Results
A dose dependent significant (P<0.01) antinociceptive activity was observed in three different concentrations 100, 200 and 300 mg/kg. Among them dose at 300 mg/kg, significantly (P<0.01) inhibited (74.94 % ) the nociception induced by acetic acid but less effective than the standard reference (84.06 % ). Tail-flick test showed that the extract at the doses 300 mg/kg showed efficient results when compared to the other two doses (100 and 200 mg/kg) with increase in the latency to response of tail to the thermal stimulation.
ss=""h4"">Conclusions
The significant antinociceptive activity of the leaf extract is due to the presence of a single active constituent in higher levels or due to the combined effect of more than one phytoconstituent. This investigation supported the ethnomedicinal claims of Delonix elata.