A Mechanism for Controlled Breakage of Under-replicated Chromosomes during Mitosis

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• 作者：Heike Duda¹ ; Meret Arter¹ ; Jiradet Gloggnitzer¹ ; Federico Teloni² ; Philipp Wild¹ ; Miguel G. Blanco³ ; Matthias Altmeyer² ; Joao Matos¹ ; ⁴ ; ^{joao.matos@bc.biol.ethz.ch}
• 关键词：cell cycle ; WEE1 ; CDK1 ; PLK1 ; DNA replication ; MUS81 ; SLX4 ; EME2 ; chromosome pulverization
• 刊名：Developmental Cell
• 出版年：2016
• 出版时间：19 December 2016
• 年：2016
• 卷：39
• 期：6
• 页码：740-755
• 全文大小：4554 K
• 卷排序：39

文摘

CDK1-dependent phosphorylation of SLX4 controls MUS81-SLX4 complex formation CDK1 activation in S phase drives MUS81-SLX4-mediated chromosome pulverization WEE1 inhibitors cause cell death partly by MUS81-SLX4-dependent chromosome breakage DNA replication and WEE1 collaboratively suppress CDK1 activity during S phase