Spatial memory is impaired by peripubertal GnRH agonist treatment and testosterone replacement in sheep

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• 作者：D. Hough^a ; M. Bellingham^a ; I.R.H. Haraldsen^b ; M. McLaughlin^c ; M. Rennie^a ; J.E. Robinson^a ; A.K. Solbakk^b ; ^d ; ^e ; N.P. Evans^a ; ^{Neil.Evans@glasgow.ac.uk}
• 关键词：Spatial orientation ; Spatial memory ; Hippocampus ; GnRH ; Puberty ; Gender dysphoria
• 刊名：Psychoneuroendocrinology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：75
• 期：Complete
• 页码：173-182
• 全文大小：1715 K
• 卷排序：75

文摘

Peripubertal GnRHa impaired long-term spatial reference memory. This GnRHa-effect was not counteracted with testosterone replacement in rams. Traverse times of spatial orientation and learning tasks were unaffected by GnRHa. GnRHa exaggerated emotional reactivity during these spatial tasks. Testosterone replacement decreased emotional reactivity and motivation in tasks.