Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2
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- 作者：Ekaterina Gavrish1 ; 5 ; 6 ; Clarissa S. Sit2 ; 5 ; Shugeng Cao2 ; Olga Kandror3 ; Amy Spoering4 ; Aaron Peoples4 ; Losee Ling4 ; Ashley Fetterman4 ; Dallas Hughes4 ; Anthony Bissell1 ; 7 ; Heather Torrey1 ; Tatos Akopian3 ; Andreas Mueller3 ; Slava Epstein1 ; Alfred Goldberg3 ; Jon Clardy2 ; jon_clardy@hms.harvard.edu" class="auth_mail ; Kim Lewis1 ; k.lewis@neu.edu" class="auth_mail
- 刊名：Chemistry & Biology
- 出版年：24 April 2014
- 年：2014
- 卷：21
- 期：4
- 页码：509-518
- 全文大小：1667 K
文摘
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Lassomycin has potent and selective bactericidal activity against M. tuberculosis
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Lassomycin is a lasso peptide but lacks the family’s characteristic knot
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Lassomycin activates ClpC1 ATP hydrolysis, uncoupling it from ClpP1P2 proteolysis