- 作者：Annabelle Teng ; MD<sup>asup> ; David Y. Lee ; MD<sup>bsup> ; Jenny Cai ; MD<sup>asup> ; Supriya S. Patel ; MD<sup>csup> ; Anton J. Bilchik ; MD ; PhD<sup>bsup> ; Melanie R. Goldfarb ; MD<sup>bsup><sup> ; sup><sup>Goldfarbm@jwci.org" class="auth_mail" title="E-mail the corresponding authorsup>
- 关键词：Colon cancer ; Young adults ; Adolescents ; AYA ; Rectal cancer
- 刊名：Journal of Surgical Research
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：205
- 期：1
- 页码：19-27
- 全文大小：277 K
sSec_2">Materials and methods
spara0015">We used the Surveillance, Epidemiology, and End Results Database to study CRC in the AYA population. We studied clinical and socioeconomic factors associated with survival.
sSec_3">Results
spara0020">Of the 11,071 cases of CRC, the most common site of the primary tumor was the rectum (25%), whereas 66.6% of the diseases were left sided. Most of the patients (72%) presented with regional or metastatic disease. However, the disease-specific survival (DSS) and the overall survival of the AYA population were comparable to those of the general population (DSS; 5- and 10-y: 64.8%, 57.3%; overall survival; 5- and 10-y: 61.5% and 52.4%). On multivariate analysis, disease stage at the time of the diagnosis was the strongest predictor of mortality. After controlling for disease stage, male gender, black race, and higher grade tumors were associated with worse survival.
sSec_4">Conclusions
spara0025">The AYA population presents with advanced distal CRC but have similar survival compared with the general population.