Gold(III) complexes with ONS-Tridentate thiosemicarbazones: Toward selective trypanocidal drugs
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- 作者：Andressa R. Rettondina ; Zumira A. Carneirob ; Ana C.R. Gonç ; alvesa ; Vanessa F. Ferreirac ; Carolina G. Oliveirac ; Angé ; lica N. Limad ; Ronaldo J. Oliveirad ; Sé ; rgio de Albuquerqueb ; Victor M. Deflonc ; Pedro I.S. Maiaa ; pedro.maia@pq.cnpq.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Gold(III) complexes ; Thiosemicarbazones ; Cruzain ; Trypanosoma cruzi ; Chagas disease
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：14 September 2016
- 年：2016
- 卷：120
- 期：Complete
- 页码：217-226
- 全文大小：1404 K
文摘
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Gold(III) complexes with ONS-tridentate thiosemicarbazone ligands were synthesized.
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The complexes were characterized by various spectrometric methods and crystallography.
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The in vitro anti-Trypanosoma cruzi activity and cytotoxicity was evaluated.
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The selectivity index of one gold(III) complex was better than that of benznidazole.
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Docking studies suggest the protease cruzain as a target for the trypanocidal action.