An Actin Network Dispatches Ciliary GPCRs into Extracellular Vesicles to Modulate Signaling

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• 作者：Andrew R. Nager¹ ; Jaclyn S. Goldstein¹ ; Vicente Herranz-Pé ; rez² ; ³ ; Didier Portran¹ ; Fan Ye¹ ; Jose Manuel Garcia-Verdugo² ; ³ ; Maxence V. Nachury¹ ; ⁴ ; ^{nachury@gmail.com}
• 关键词：cilia ; extracellular vesicles ; GPCR ; Hedgehog ; BBSome ; exosomes ; actin ; myosin 6 ; drebrin
• 刊名：Cell
• 出版年：2017
• 出版时间：12 January 2017
• 年：2017
• 卷：168
• 期：1-2
• 页码：252-263.e14
• 全文大小：4186 K
• 卷排序：168

文摘

Signal-dependent exit of GPCRs from cilia proceeds through retrieval or ectocytosis GPCRs that cannot be retrieved back into the cell are instead ectocytosed Actin, myosin 6, and drebrin mediate the scission of ectosomes from cilia tips Hedgehog signaling fails when both ectocytosis and retrieval are blocked