Bioconcentration, metabolism and half-life time of the human therapeutic drug diltiazem in rainbow trout Oncorhynchus mykiss
详细信息 查看全文
- 作者：Christoph Steinbach ; steinbach@frov.jcu.cz" class="auth_mail" title="E-mail the corresponding author ; Roman Grabic ; Ganna Fedorova ; Olga Koba ; Oksana Golovko ; Katerina Grabicova ; Hana Kocour Kroupova
- 关键词：Calcium channel blocker ; Metabolites ; Half-life ; Bioconcentration factor
- 刊名：Chemosphere
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：144
- 期：Complete
- 页码：154-159
- 全文大小：579 K
文摘
- •
Diltiazem had a low level of bioconcentration (maximal BCF of 194 in the kidney).
- •
The half-life of diltiazem followed the order muscle > kidney > liver.
- •
Diltiazem metabolites detected in trout were similar to those reported in mammals.