Surfactant replacement therapy with a minimally invasive technique: Experience in a tertiary hospital

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• 作者：F.J. Canals Candela ; ^{canals.candela@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; C. Vizcaí ; no Dí ; az ; M.J. Ferrá ; ndez Berenguer ; M.I. Serrano Robles ; C. Vá ; zquez Gomis ; J.L. Quiles Durá
• 关键词：Minimally invasive therapy ; Pulmonary surfactant ; Respiratory distress syndrome ; Newborn ; Infant ; Premature
• 刊名：Anales de Pediatría (English Edition)
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：84
• 期：2
• 页码：79-84
• 全文大小：458 K

文摘

The minimally invasive technique known as MIST (Minimally Invasive Surfactant Therapy), is a method which allows surfactant to be administered to a patient connected to non-invasive respiratory support. Use of this therapy is growing in Neonatal Units, as it reduces the intubation rate and the pathology associated with intubation and allows surfactant to be administered to patients in need.

Patients and methods

In 2013 and 2014 in the Hospital General Universitario de Elche surfactant was delivered using this method to 19 patients, 5 of whom had a gestational age of 28 or less weeks. Data were compared with a historical cohort consisting of 28 patients with Respiratory Distress Syndrome treated initially with non-invasive respiratory support.

Results

No incidents were recorded that caused interruption of administration. A reduction in the fraction of inspired oxygen was observed in all cases after surfactant administration. Fewer intubations in the first 72 h of life were found in the treatment group compared to the control group (42% vs. 54%).

Discussion

The experience in the Hospital General Universitario de Elche shows that administration of surfactant using the MIST technique is a reproducible method of treatment, which allows surfactant distribution during spontaneous breathing with non-invasive respiratory support.