Timing of Gonadectomy in Patients with Complete Androgen Insensitivity Syndrome-Current Recommendations and Future Directions

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• 作者：Vrunda Patel ; MD¹ ; ^{Vrunda.Patel@medstar.net" class="auth_mail" title="E-mail the corresponding author} ; Rachel Kastl Casey ; MD² ; Veronica Gomez-Lobo ; MD²
• 关键词：Complete androgen insensitivity syndrome ; Gonadectomy ; Testicular feminization syndrome
• 刊名：Journal of Pediatric and Adolescent Gynecology
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：29
• 期：4
• 页码：320-325
• 全文大小：444 K

文摘

This review highlights the controversy regarding timing of gonadectomy in patients with complete androgen insensitivity syndrome (CAIS). We will review the published literature regarding frequency of gonadal malignancy and summarize historical findings. Recent research suggests that gonadectomy may be deferred until adulthood due to the low risk of malignancy. An algorithm is also provided to help guide clinicians in management of patients with complete androgen insensitivity syndrome who have deferred gonadectomy.