- 作者：Yan KANG ; Qing-qing HONG ; Wei-ran CHAI ; Yong-lun FU ; Ai AI ; Qiu-ju CHEN ; chenqiuju2865@hotmail.com ; Yan-ping KUANG ; Kuangyanp@126.com
- 关键词：clomiphene citrate (CC) ; human menopausal gonadotrophin (hMG) ; frozen-thawed embryo transfer (FET) ; short protocol
- 刊名：Journal of Reproduction and Contraception
- 出版年：2013
- 出版时间：March, 2013
- 年：2013
- 卷：24
- 期：1
- 页码：10-20
- 全文大小：318 K
Objective
To compare the results of a novel regimen of human menopausal gonadotrophin (hMG) in combination with clomiphene citrate (CC) in mid-to-late follicular phase with those of a short protocol of GnRH agonist (GnRHa) and hMG used for IVF.Methods
In the retrospective study, 842 patients undergoing IVF were collected and classified into two groups: hMG in combination with CC in mid-to-late follicular phase (group A, n=319) and short protocol of GnRHa-hMG (group B, n=523). The main outcome measures were ovarian responses in stimulation cycles and pregnancy outcomes in subsequent frozen-thawed embryo transfer (FET) cycles.
Results
In group A, the serum LH concentration on day 8-10 was similar with that on the day of hCG administration (2.43¡À 1.92 IU vs 2.51 ¡À 2.05 IU). The number of mature follicles and oocytes retrieved was significantly lower in group A than in group B while the fertilization rate and the cleavage rate were comparable. The clinical pregnancy rate (47.79 % vs 48.04 % ), the implantation rate (32.49 % vs 33.11 % ) and the cumulative pregnancy rate (58.09 % vs 60.22 % ) were respectively similar in group A and group B.
Conclusions
hMG in combination with CC in mid-to-late follicular phase results in the same pregnancy outcome as short protocol. The novel protocol may take the advantage of eliminating the occurrence of a premature endogenous LH surge.