Membrane receptor cross talk in gonadotropin-, IGF-I-, and insulin-mediated steroidogenesis in fish ovary: An overview

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• 作者：Dilip Mukherjee^a ; ^{dilipmukher@rediffmail.com} ; Suravi Majumder^a ; Sujata Roy Moulik^a ; ^b ; Puja Pal^a ; ^c ; Shreyasi Gupta^a ; Payel Guha^a ; Dhynendra Kumar^d
• 关键词：Ovary ; Steroidogenesis ; Gonadotropin ; G protein-coupled receptor ; IGF-I ; Insulin ; Fish
• 刊名：General and Comparative Endocrinology
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：240
• 期：Complete
• 页码：10-18
• 全文大小：1160 K
• 卷排序：240

文摘

Gonadotropin regulation of fish ovarian steroidogenesis mediated through GPCR revealed interactions of cAMP, calmodulin, CaMKs and MAP kinase pathways. Gonadotropin in fish ovary trans-activate membrane-bound EGFR and activate ERK1/2 signaling for steroid production. GonadotrtH-induced trans-activation of EGFR in the fish ovary uniquely requires matrix-metalloproteinase-mediated release of EGF. IGF-I and insulin alone can induce fish ovarian steroidogenesis through activation of PI3 kinase and MAP kinase.