Exacerbated mechanical allodynia in rats with depression-like behavior

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• 作者：Qing Zeng ; Shuxing Wang ; Grewo Lim ; Liling Yang ; Ji Mao ; Backil Sung ; Yang Chang ; Jeong-Ae Lim ; Gongshe Guo ; Jianren Mao
• 关键词：Allodynia ; Melatonin ; Depression ; Anterior cingular cortex ; Neuropathic pain ; Nerve injury ; WKY rat
• 刊名：Brain Research
• 出版年：2008
• 出版时间：20 March 2008
• 年：2008
• 卷：1200
• 期：Complete
• 页码：27-38
• 全文大小：955 K

文摘

Although a clinical connection between pain and depression has long been recognized, how these two conditions interact remains unclear. Here we report that both mechanical allodynia and depression-like behavior were significantly exacerbated after peripheral nerve injury in Wistar-Kyoto (WKY) rats, a genetic variation of Wistar rats with demonstrable depression-like behavior. Administration of melatonin into the anterior cingular cortex contralateral to peripheral nerve injury prevented the exacerbation of mechanical allodynia with a concurrent improvement of depression-like behavior in WKY rats. Moreover, there was a lower plasma melatonin concentration and a lower melatonin receptor expression in the anterior cingular cortex in WKY rats than in Wistar rats. These results suggest that there exists a reciprocal relationship between mechanical allodynia and depression-like behavior and the melatoninergic system in the anterior cingular cortex might play an important role in the interaction between pain and depression.