Inhibition of melanization by a Nasonia defensin-like peptide: Implications for host immune suppression
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- 作者：Caihuan Tian ; Lei Wang ; Gongyin Ye ; Shunyi Zhu
- 关键词：Innate immunity ; Nasonin-3 ; Parasitoid ; Recombinant expression ; Cysteine-stabilized α ; -helical and β ; -sheet motif
- 刊名：Journal of Insect Physiology
- 出版年：2010
- 出版时间：December 2010
- 年：2010
- 卷：56
- 期：12
- 页码：1857-1862
- 全文大小：447 K
文摘
The parasitic wasp Nasonia vitripennis suppresses host immune mechanisms that include melanization reactions. Melanization is an important immune response of hosts induced by wasp infection and thus its inhibition represents a successful strategy for parasitism. However, the molecular basis associated with such inhibition is largely unknown in N. vitripennis. Here, we report recombinant expression, structural and functional characterization of a Nasonia-derived defensin-like peptide (called nasonin-3) whose recombinant product exerts inhibitory effect on host melanization. The possible role of nasonin-3 in immune suppression is also discussed.