Modulation of actomyosin ATPase by goniodomin A differs in types of cardiac myosin

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• 作者：Yasuda ; Masako ; Nakatani ; Keigo ; Matsunaga ; Kimihiro ; Murakami ; Masahiro ; Momose ; Kazutaka ; et. al.
• 关键词：Goniodomin A ; Actomyosin ATPase ; Ventricle ; Atrium ; Troponin&ndash ; tropomyosin complex
• 刊名：European Journal of Pharmacology
• 出版年：1998
• 出版时间：April 3, 1998
• 年：1998
• 卷：346
• 期：1
• 页码：119-123
• 全文大小：112 K

文摘

Goniodomin A causes the conformational change of actin to modify actomyosin ATPase activity [Furukawa, K.-I., Sakai, K., Watanabe, S., Maruyama, K., Murakami, M., Yamaguchi, K., Ohizumi, Y., 1993. Goniodomin A induces modulation of actomyosin ATPase activity mediated through conformational change of actin. J. Biol. Chem. 268, 26026–26031]. Goniodomin A inhibited the ATPase activities of atrial myofibrils, myosin B and reconstituted actomyosin in a concentration-dependent manner. Interestingly, these ATPase activities of ventricular muscle were enhanced by goniodomin A (3×10⁻⁸–3×10⁻⁷ M), but were decreased when the concentration was further raised. The stimulatory effect of goniodomin A was significantly inhibited by troponin–tropomyosin complex. These results suggest that goniodomin A affects actin to modify cardiac actomyosin ATPase activity, and that this modulation differs in types of cardiac myosin.