‘Interleukin-4 gene polymorphism and its relation to periodontal disease in a Brazilian population of African heritage’
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- 作者：Cruvinel Pontes ; Carla ; Gonzales ; Jose R. ; Novaes Jr ; Arthur Belé ; m ; Taba Jú ; nior ; Má ; rio ; et. al.
- 关键词：Polymorphism ; IL-4 ; Periodontal disease ; Genetic risk factors
- 刊名：Journal of Dentistry
- 出版年：2004
- 出版时间：March, 2004
- 年：2004
- 卷：32
- 期：3
- 页码：241-246
- 全文大小：135 K
文摘
Objectives. Host modifying factors, such as genetic predisposition, may increase severity of periodontitis. Genetic polymorphisms in interleukin-4 (IL-4) genes seem to influence host response to microbial challenge. Two IL-4 polymorphisms were found in association with asthma and atopy, and later with aggressive periodontitis in Caucasians. There seems to be a trend for racial differences regarding polymorphisms. Therefore, this study aimed to evaluate if these IL-4 polymorphisms were associated with periodontal disease in a Brazilian population of African heritage.