Evaluation of activity of triclabendazole against Taenia solium metacestode in naturally infected pigs

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• 作者：Ana Vargas-Calla¹ ; Luis A. Gomez-Puerta¹ ; ^{lucho92@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Juan Calcina¹ ; Omar Gonzales-Viera¹ ; Cesar Gavidia¹ ; Maria T. Lopez-Urbina¹ ; Hector H. Garcia² ; ³ ; Armando E. Gonzalez¹
• 关键词：Taenia solium ; Cysticercosis ; Triclabendazole ; Oxfendazole ; Treatment
• 刊名：Asian Pacific Journal of Tropical Medicine
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：9
• 期：1
• 页码：23-26
• 全文大小：712 K

文摘

To assess the efficacy of triclabendazole (TCBZ) in porcine cysticercosis.

Methods

Eighteen naturally infected cysticercosis pigs were divided into 3 groups of 6 individuals each. The first group was treated orally with TCBZ at a single dose of 30 mg/kg of body weight, the second group was treated orally with oxfendazole at a single dose of 30 mg/kg of body weight and the third group received a placebo (control group). All animals were kept under the same management conditions. The pigs were euthanized 17 wk post-treatment and the number of surviving cysts in muscles was assessed and compared between groups.

Results

All pigs treated with oxfendazole had only degenerated cysts in their carcasses. In contrast, TCBZ had very little effect against the parasitic cysts. Cysts from pigs in the TCBZ group looked apparently normal after treatment. However, histological evaluation showed a mild to moderate degree of inflammation.

Conclusions

TCBZ is not an efficacious drug against Taenia solium cysticercosis in swine using a single dose.