Inexpensive anti-cysticercosis vaccine: S3Pvac expressed in heat inactivated M13 filamentous phage proves effective against naturally acquired Taenia solium porcine cysticercosis

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• 作者：Julio Morales ; José ; Juan Martí ; nez ; Karen Manoutcharian ; Marisela Herná ; ndez ; Agnes Fleury ; Goar Gevorkian ; Gonzalo Acero ; Abel Blancas ; Andrea Toledo ; Jacquelynne Cervantes ; Victor Maza
• 关键词：Vaccine ; Taenia solium cysticercosis ; Control
• 刊名：Vaccine
• 出版年：2008
• 出版时间：2 June 2008
• 年：2008
• 卷：26
• 期：23
• 页码：2899-2905
• 全文大小：319 K

文摘

In search of reducing vaccine production costs’, a recombinant M13 phage version of the anti-cysticercosis tripeptide vaccine (S3Pvac) was developed. The efficacy of S3Pvac-Phage vs. placebo was evaluated in a randomized trial that included 1047 rural pigs in 16 villages of Central Mexico. Three to five months after vaccination 530 pigs were examined by tongue inspection. At 5–27 months of age, 331 pigs (197 vaccinated/134 controls) were inspected at necropsy. Vaccination reduced 70 % the frequency of tongue cysticercosis and, based on necropsy, 54 % of muscle-cysticercosis and by 87 % the number of cysticerci.