Membrane Lipids in Presynaptic Function and Disease

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• 作者：Elsa Lauwers¹ ; ² ; ^{elsa.lauwers@cme.vib-kuleuven.be" class="auth_mail" title="E-mail the corresponding author} ; Rose Goodchild¹ ; ² ; ^{rose.goodchild@cme.vib-kuleuven.be" class="auth_mail" title="E-mail the corresponding author} ; Patrik Verstreken¹ ; ² ; ^{patrik.verstreken@cme.vib-kuleuven.be" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Neuron
• 出版年：2016
• 出版时间：6 April 2016
• 年：2016
• 卷：90
• 期：1
• 页码：11-25
• 全文大小：1674 K

文摘

Lipids are the most abundant organic compounds in the brain. The brain has a unique lipidome, and changes in lipid concentration, organization, and metabolism are associated with many neuronal diseases. Here, we discuss recent advances in understanding presynaptic membrane lipid organization, centered on illustrative examples of how the lipids themselves regulate membrane trafficking and control protein activity. This insight highlights that presynaptic terminals are membrane-remodeling machines and that cooperation between lipid and protein molecules underlies presynaptic activity.