The Risk Stratification and Stroke Prevention Therapy Care Gap in Canadian Atrial Fibrillation Patients

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• 作者：Paul Angaran ; MD^a ; Paul Dorian ; MD^a ; Mary K. Tan ; MSc^b ; Charles R. Kerr ; MD^c ; Martin S. Green ; MD^d ; David J. Gladstone ; MD ; PhD^e ; L. Brent Mitchell ; MD^f ; Carl Fournier ; MD^g ; Jafna L. Cox ; MD^h ; Mario Talajic ; MDⁱ ; Peter J. Lin ; MD^b ; ^j ; Anatoly Langer ; MD ; MSc^b ; Lianne Goldin ; CCMEP^b ; Shaun G. Goodman ; MD ; MSc^a ; ^b ; ^{goodmans@chrc.net" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Canadian Journal of Cardiology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：32
• 期：3
• 页码：336-343
• 全文大小：359 K

文摘

Canadian atrial fibrillation (AF) guidelines recommend that all AF patients be risk stratified with respect to stroke and bleeding, and that most should receive antithrombotic therapy.

Methods

As part of the Canadian Facilitating Review and Education to Optimize Stroke Prevention in Atrial Fibrillation (FREEDOM AF) chart audit, data were collected on 4670 patients ≥ 18 years old without significant valvular heart disease from the primary care practices of 474 physicians (February to September, 2011).

Results

Physicians did not provide an estimate of stroke and bleeding risk in 15% and 25% of patients, respectively. When risks were provided, they were on the basis of a predictive stroke and bleeding risk index in only 50% and 26% of patients, respectively. There were over- and underestimation of stroke and bleeding risk in a large proportion of patients. Antithrombotic therapy included warfarin (90%); 24% of patients had a time in the therapeutic range (TTR) < 50%, 9% between 50% and 60%, 11% between 60% and 70%, and 56% had a TTR ≥ 70%.

Conclusions

In a large Canadian AF population, primary care physicians did not provide a stroke or bleeding risk in a substantial proportion of their AF patients. When estimates were provided, they were on the basis of a predictive stroke and bleeding risk index in less than half of the patients. Furthermore, there was under- and overestimation of stroke and bleeding risk in a substantial proportion of patients. As many as 1 in 3 patients receiving warfarin have their TTR < 60%. These findings suggest an opportunity to enhance knowledge translation to primary care physicians.