Bioengineering methods for myocardial regeneration

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• 作者：Hesam Parsa^a ; ¹ ; Kacey Ronaldson^a ; ¹ ; Gordana Vunjak-Novakovic^a ; ^b ; ^{gv2131@columbia.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Tissue engineering ; Human induced pluripotent stem cells ; Cardiomyocyte ; Bioreactor ; Electro-mechanical stimulation ; Cell and tissue delivery to the heart
• 刊名：Advanced Drug Delivery Reviews
• 出版年：2016
• 出版时间：15 January 2016
• 年：2016
• 卷：96
• 期：Complete
• 页码：195-202
• 全文大小：869 K

文摘

The challenging task of heart regeneration is being pursued in three related directions: derivation of cardiomyocytes from human stem cells, in vitro engineering and maturation of cardiac tissues, and development of methods for controllable cell delivery into the heart. In this review, we focus on tissue engineering methods that recapitulate biophysical signaling found during normal heart development and maturation. We discuss the use of scaffold–bioreactor systems for engineering functional human cardiac tissues, and the methods for delivering stem cells, cardiomyocytes and engineered tissues into the heart.