Streptococcus gordonii induces nitric oxide production through its lipoproteins stimulating Toll-like receptor 2 in murine macrophages

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• 作者：Hyun Young Kim^a ; Jung Eun Baik^a ; Ki Bum Ahn^a ; Ho Seong Seo^b ; Cheol-Heui Yun^c ; Seung Hyun Han^a ; ^{shhan-mi@snu.ac.kr}
• 关键词：Streptococcus gordonii ; Lipoprotein ; Lipoteichoic acid ; Nitric oxide ; Macrophage
• 刊名：Molecular Immunology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：82
• 期：Complete
• 页码：75-83
• 全文大小：1470 K
• 卷排序：82

文摘

Lipoprotein-deficient S. gordonii induces less NO production than the wild-type in macrophages. Lipoprotein-deficient S. gordonii weakly induces NF-κB activation, IFN-β expression and STAT1 phosphorylation. Lipoprotein of S. gordonii is a major TLR2 ligand inducing NO production in macrophages.