Selected azaphenothiazines inhibit delayed type hypersensitivity and carrageenan reaction in mice
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- 作者：Jolanta Artyma ; Iwona E. Kochanowskaa ; Maja Kociębaa ; Ewa Zaczyńskaa ; Michał Zimeckia ; zimecki@iitd.pan.wroc.pl" class="auth_mail" title="E-mail the corresponding author ; Małgorzata Jeleńb ; Beata Morak-Młodawskab ; Krystian Plutab
- 关键词：anti-MDR ; anti-multidrug resistance ; cFa ; complete Freund's adjuvant ; DEX ; dexamethasone ; DMSO ; dimethylsulfoxide ; DTH ; delayed type hypersensitivity ; iFa ; incomplete Freund's adjuvant ; i.p. ; intraperitoneally ; LPS ; lipopolysaccharide ; MLR ; mixed lymphocyte reaction ; OVA ; ovalbumin ; PBMC ; peripheral blood mononuclear cells ; PHA ; phytohemagglutinin ; s.c. ; subcutaneously
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：40
- 期：Complete
- 页码：265-268
- 全文大小：584 K
文摘
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The phenothiazine structure modified with the pyridine and quinoline rings
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Azaphenothiazines suppress elicitation of delayed type hypersensitivity.
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Azaphentiothiazines inhibit carrageenan-induced foot pad inflammation.
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Azaphenothiazines are potential anti-inflammatory therapeutics.
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The quinoline moiety conditions a better activity than the pyridine ring.