Placebo-controlled trials and the Declaration of Helsinki

详细信息    查看全文

• 作者：Lewis ; John A ; Jonsson ; Bertil ; Kreutz ; Gottfried ; Sampaio ; Cristina ; van Zwieten-Boot ; Barbara
• 刊名：The Lancet
• 出版年：2002
• 出版时间：April 13, 2002
• 年：2002
• 卷：359
• 期：9314
• 页码：1337-1340
• 全文大小：72.8 K

文摘

A revised version of the Declaration of Helsinki, issued in October, 2000, remains a vital expression of medical ethics, and deserves unanimous support. A strict interpretation of the declaration seems to rule out clinical trials that use a placebo control group whenever licensed therapeutic methods already exist, preferring active controls. Although the efficacy of some new medicines can be satisfactorily established without the use of a placebo, for others the judicious use of placebo remains essential to establish their effectiveness.