The molecular complexity of glucocorticoid actions in inflammation — a four-ring circus

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• 作者：Goulding ; Nicolas J
• 关键词：Anx-A1 ; annexin I ; AP-1 ; activating protein 1 ; CBP ; CREB-binding protein ; CREB ; cAMP responsive element binding protein ; GILZ ; glucocorticoid-induced leucine zipper ; GITR ; glucocorticoid-induced TNF receptor-relat
• 刊名：Current Opinion in Pharmacology
• 出版年：2004
• 出版时间：December, 2004
• 年：2004
• 卷：4
• 期：6
• 页码：629-636
• 全文大小：140 K

文摘

Glucocorticoids have been the mainstay of anti-inflammatory therapy for the past 50 years despite the significant risks associated with their long-term use. Recent research into the molecular mechanisms of action of these compounds can be aggregated into two major themes: first, those that focus on the involvement of the glucocorticoid receptor in regulating the transcription of pro-inflammatory genes; and second, studies that seek to identify alternative pathways of glucocorticoid action either via the induction of anti-inflammatory mediators or through rapid non-genomic mechanisms. Understanding the temporal-spatial patterns of these multiple mechanisms on relevant cell types will be key to explaining the profound effects that these four-ring steroids exert on the inflammatory process.