TGF¦Â and BMP signaling in cardiac cushion formation: Lessons from mice and chicken

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• 作者：Boudewijn P.T. Kruithof ; Sjoerd N. Duim ; Asja T. Moerkamp ; Marie-Jos¨¦ Goumans
• 关键词：Cardiac cushion formation ; Mouse ; Chicken ; BMP ; TGFbeta ; EMT
• 刊名：Differentiation
• 出版年：2012
• 出版时间：July, 2012
• 年：2012
• 卷：84
• 期：1
• 页码：89-102
• 全文大小：1036 K

文摘

Cardiac cushion formation is crucial for both valvular and septal development. Disruption in this process can lead to valvular and septal malformations, which constitute the largest part of congenital heart defects. One of the signaling pathways that is important for cushion formation is the TGF¦Â superfamily. The involvement of TGF¦Â and BMP signaling pathways in cardiac cushion formation has been intensively studied using chicken in vitro explant assays and in genetically modified mice. In this review, we will summarize and discuss the role of TGF¦Â and BMP signaling components in cardiac cushion formation.