Meglumine catalyzed one-pot green synthesis of novel 4,7-dihydro-1H-pyrazolo[3,4-b]pyridin-6-amines

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• 作者：Santhosh Govindaraju ; Sumaiya Tabassum ; Riyaz-ur-Rahaman Khan ; Mohamed Afzal Pasha ; ^{m_af_pasha@ymail.com}
• 关键词：One-pot five-component reaction ; Substituted phenylacetonitriles ; Meglumine ; Pyrazolopyridin-6-amines ; Ethanol
• 刊名：Chinese Chemical Letters
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：28
• 期：2
• 页码：437-441
• 全文大小：321 K
• 卷排序：28

文摘

Meglumine efficiently catalyzes the one-pot, five-component reaction of hydrazine, ethyl acetoacetate, aryl aldehydes, substituted phenylacetonitriles and ammonium acetate in ethanol at room temperature to afford novel 4,7-dihydro-1H-pyrazolo[3,4-b]pyridin-6-amine derivatives. The present approach offers several advantages such as shorter reaction durations, low cost, excellent yields, milder reaction conditions, simple workup procedure and is environment friendly. All the synthesized derivatives are characterized by IR, 1H NMR, 13C NMR, HRMS and CHN analysis.