Molecular architecture and solid-state properties of novel biocompatible PBS-based copolyesters containing sulphur atoms

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• 作者：Michelina Soccio ; Nadia Lotti ; Massimo Gazzano ; Marco Govoni ; Emanuele Giordano ; Andrea Munari
• 关键词：Poly(butylene succinate) ; Thiodiethylene glycol ; Reactive blending ; Block copolymers ; Biocompatibility
• 刊名：Reactive and Functional Polymers
• 出版年：2012
• 出版时间：November, 2012
• 年：2012
• 卷：72
• 期：11
• 页码：856-867
• 全文大小：1164 K

文摘

Poly(butylene/thiodiethylene succinate) block copolymers (PBSPTDGS), prepared by reactive blending of the parent homopolymers (PBS and PTDGS) in the presence of Ti(OBu)₄, underwent molecular and solid-state characterization, in order to investigate the effects of the transesterification reactions. ¹³C NMR analysis demonstrated the formation of copolymers whose degree of randomness increased with the mixing time. Thermal measurements showed that all the samples were semicrystalline, with a soft amorphous phase and a rigid crystal phase. WAXD measurements indicated that the copolymers are characterized by the presence of a pure PBS crystal phase, with the exception of physical mixture. The mechanical properties were related to degree of crystallinity. The random copolymer, characterized by the lowest crystallinity degree, exhibits the lowest elastic modulus and the highest deformation at break. When evaluated for indirect cytotoxicity, all the polymers under investigation appeared entirely biocompatible. In addition, positive results from cellular adhesion and proliferation assays carried out with H9c2 cells seeded and grown up to 14 days in culture over films of PBSPTDGS30 and PBSPTDGS240 demonstrated that these new materials might be of interest for tissue engineering applications.