A SNP from the DAT1 gene interacted with measures of early life stress to influence depressive symptoms in children.
SGA and a SNP from the dopamine transporter gene DAT1 had an interactive effect on children's depressive symptoms.
Depression symptoms were greater in children born SGA who are T homozygous for the rs1042098 SNP.
Adverse antenatal environments leading to low birth weight may exacerbate the effects of certain DAT1 variants on depression.