Anti-inflammatory activity of Chrysanthemum indicum

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• 作者：Do Yeon Lee ; Goya Choi ; Taesook Yoon ; Myeong Sook Cheon ; Byung Kil Choo ; Ho Kyoung Kim
• 关键词：Chrysanthemum indicum ; Skin inflammation ; Anti-inflammatory activity ; 12-O-tetradecanoyl-phorbol-13-acetate (TPA) ; Dermatitis
• 刊名：Journal of Ethnopharmacology
• 出版年：2009
• 出版时间：4 May 2009
• 年：2009
• 卷：123
• 期：1
• 页码：149-154
• 全文大小：2309 K

文摘

Aim of the study

Although Chrysanthemum indicum Linné (Compositae) has long been used in traditional Korean, Chinese, Japanese medicine to treat various immune-related diseases the underlying mechanism(s) by which these effects are induced remains to be defined in vivo model system. We investigated the effects of 70 % ethanolic extract from Chrysanthemum indicum Linné (CIE) on skin inflammation in mice.

Materials and methods

Production of pro-inflammatory cytokines (TNF-α and IL-1β), activation of myeloperoxidase, and histological assessment were examined in acute and chronic skin inflammation using 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced mouse ear edema.

Results

CIE inhibited topical edema in the mouse ear, following administration at 200 mg/kg (i.p.), leading to substantial reductions in skin thickness and tissue weight, inflammatory cytokine production, neutrophil-mediated myeloperoxidase activity, and various histopathological indicators. Furthermore, CIE was effective at reducing inflammatory damage induced by chronic TPA exposure.

Conclusions

These results demonstrate that CIE is an effective anti-inflammatory agent in murine phorbol ester-induced dermatitis, and suggest that the extract may have therapeutic potential in a variety of immune-related cutaneous diseases.