The first minutes in the life of a peroxisomal matrix protein
详细信息 查看全文
- 作者：Ana F. Diasa ; b ; c ; Tâ ; nia Franciscoa ; b ; Tony A. Rodriguesa ; b ; Clá ; udia P. Groua ; b ; Jorge E. Azevedoa ; b ; c ; jazevedo@ibmc.up.pt" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACOX ; acyl-CoA oxidase ; AO ; alcohol oxidase ; CCS ; copper chaperone of SOD1 ; DTM ; docking/translocation machinery ; Gpd1p ; glycerol-3-phosphate dehydrogenase 1 ; LDHA/B/Bx ; lactate dehydrogenase isoforms A ; B and B readthrough-extended ; respectively ; PIM ; peroxisomal import machinery ; Pnc1p ; nicotinamidase ; PTS ; protein targeting signal ; SOD1 ; Cu/Zn superoxide dismutase ; TPR ; tetratricopeptide repeat ; UOX ; urate oxidase.
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：1863
- 期：5
- 页码：814-820
- 全文大小：438 K
文摘
- •
The vast majority of peroxisomal matrix proteins are homo-oligomers.
- •
How these proteins are sorted to the organelle has been a matter of debate.
- •
We argue that this sorting pathway is best explained by a monomer-based import mechanism.