Severe hypertriglyceridemia does not protect from ischemic brain injury in gene-modified hypertriglyceridemic mice
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- 作者：Yong Chena ; 1 ; Ping Liua ; 1 ; Rong Qib ; Yu-hui Wangb ; George Liub ; vangeorgeliu@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Chun Wanga ; ronaldnju@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ischemic stroke ; Extreme hypertriglyceridemia ; ApoCIII transgene ; GPIHBP1 knockout ; transient middle cerebral artery occlusion
- 刊名：Brain Research
- 出版年：2016
- 出版时间：15 May 2016
- 年：2016
- 卷：1639
- 期：Complete
- 页码：161-173
- 全文大小：9320 K
文摘
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Hypertriglyceridemia (HTG) are found to relate to good outcomes after ischemic stroke.
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This HTG paradox was evaluated in two gene-modified mouse models of HTG.
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Our results showed that HTG had no effect on brain ischemia-reperfusion injury.
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HTG paradox probably represents residual unmeasured confounding factors.