Cardiomyocyte-endothelial cell control of lipoprotein lipase
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- 作者：Amy Pei-Ling Chiu ; Andrea Wan ; Brian Rodrigues ; rodrigue@mail.ubc.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Heparanase ; GPIHBP1 ; VEGF ; Diabetic cardiomyopathy ; STZ diabetes
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：1861
- 期：10
- 页码：1434-1441
- 全文大小：629 K
文摘
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Lipoprotein lipase is a key perpetrator responsible for organizing disequilibrium in the heart during diabetes.
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EC and cardiomyocytes support each other to promote lipoprotein lipase transfer to the vascular lumen.
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Understanding mechanisms that regulate lipoprotein lipase could provide novel targets for treatment of diabetic cardiomyopathy.