Activation of GPR30 improves exercise capacity and skeletal muscle strength in senescent female Fischer344 × Brown Norway rats
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- 作者：Hao Wanga ; b ; haowang@wakehealth.edu" class="auth_mail" title="E-mail the corresponding author ; Allan Alencara ; e ; 1 ; allankdc@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Marina Lina ; mlin@wakehealth.edu" class="auth_mail" title="E-mail the corresponding author ; Xuming Suna ; xsun@wakehealth.edu" class="auth_mail" title="E-mail the corresponding author ; Roberto T. Sudoa ; e ; 1 ; rtsudo@icb.ufrj.br" class="auth_mail" title="E-mail the corresponding author ; Gisele Zapata-Sudoa ; e ; 1 ; gzsudo@oi.com.br" class="auth_mail" title="E-mail the corresponding author ; Dawn A. Lowef ; lowex017@umn.edu" class="auth_mail" title="E-mail the corresponding author ; Leanne Grobana ; b ; c ; d ; lgroban@wakehealth.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：GPR30 ; Exercise capacity ; Skeletal muscle ; Ovariectomy ; Fischer344 × ; Brown Norway rat
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：17 June 2016
- 年：2016
- 卷：475
- 期：1
- 页码：81-86
- 全文大小：972 K
文摘
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GPR30 activation reverses adverse effects of OVX on exercise capacity in rats.
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GPR30 activation prevents OVX-related reductions in peak twitch in soleus muscle.
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GPR30 activation inhibits OVX-induced decrease in HSP expression in soleus muscle.
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GPR30 activation increases HSP expression in cultured L6 skeletal muscle cells.