A relation between osteoclastogenesis inhibition and membrane-type estrogen receptor GPR30
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- 作者：Masaaki Masuharaa ; Takao Tsukaharaa ; Kazuo Tomitaa ; Minami Furukawaa ; b ; Shouichi Miyawakib ; Tomoaki Satoa ; tomsato@dent.kagoshima-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：RANKL ; receptor activator of NF-κB ligand ; M-CSF ; macrophage colony-stimulating factor ; QOL ; quality of life ; GPCR ; G-protein coupled receptor ; BMC ; bone marrow cell ; TRAP ; tartrate-resistant acid phosphatase
- 刊名：Biochemistry and Biophysics Reports
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：8
- 期：Complete
- 页码：389-394
- 全文大小：612 K
文摘
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Flavonoids can prevent osteoporosis, but the precise mechanism remains unknown.
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The major flavonoid quercetin inhibited osteoclastogenesis.
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The inhibition was entirely rescued by GPR30 antagonism.
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GPR30 has a key role in mechanism of osteoclastogenesis prevention by quercetin.