Simultaneous determination of gabapentin, pregabalin, vigabatrin, and topiramate in plasma by HPLC with fluorescence detection
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- 作者：Bo&scaron ; tjan Martinc ; Robert Ro&scaron ; kar ; Iztok Grabnar ; Toma啪 Vovk ; tomaz.vovk@ffa.uni-lj.si" class="auth_mail
- 关键词：Gabapentin ; Pregabalin ; Vigabatrin ; Topiramate ; Fluorescence detection ; Therapeutic drug monitoring
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：1 July 2014
- 年：2014
- 卷：962
- 期：Complete
- 页码：82-88
- 全文大小：856 K
文摘
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Gabapentin, pregabalin, vigabatrin, and topiramate were determined in plasma.
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Simple NBD-Cl derivatization method using HPLC and FLD was developed.
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NBD-Cl derivatization products were identified using MS spectrometry.
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The method meets validation criteria, good agreement was found with reference method.
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The method is suitable for determination of plasma concentration of studied drugs.