Measles vaccination effectiveness among children under 5 years of age in Kampala, Uganda

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• 作者：Ezekiel Mupere ; Charles Karamagi ; George Zirembuzi ; Mark Grabowsky ; Rik L. de Swart ; Miriam Nanyunja and Harriet Mayanja
• 关键词：Measles vaccination effectiveness ; Attack rates ; Filter paper blood samples
• 刊名：Vaccine
• 出版年：2006
• 出版时间：8 May 2006
• 年：2006
• 卷：24
• 期：19
• 页码：4111-4115
• 全文大小：98 K

文摘

Measles control remains a great challenge in Uganda. We conducted a prospective study among household contacts aged 9–59 months to assess measles vaccination effectiveness. Index cases were measles patients seen in Kampala hospitals in 1999. Measles was diagnosed in 37/43 (86 % ) of unvaccinated and in 33/145 (23 % ) of vaccinated exposed contacts, respectively. Vaccination effectiveness was 74 % (95 % CI; 64–81), which was lower than expected. This may indicate the need for strengthening of the cold chain and/or introduction of a second opportunity for measles vaccination, either as part of the routine immunization program or in the form of supplementary immunization activities.